H2N2V1, Main, Exploration, bibRecord, 002D84

[The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years].

Identifieur interne : 002D84 ( Main/Exploration ); précédent : 002D83; suivant : 002D85

[The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years].

Auteurs : E P Grigor'Eva ; Iu A. Desheva ; S A Donina ; A N Na Khin ; A R Rekstin ; I B Barantseva ; E A Zavitkova ; T M Moskvicheva ; V G Zhavoronkov ; L G Rudenko

Source :

Voprosy virusologii [ 0507-4088 ]

RBID : pubmed:12271721

Descripteurs français

KwdFr :
- Administration par voie nasale, Adolescent, Anticorps antiviraux (analyse), Calendrier vaccinal, Enfant, Grippe humaine (), Grippe humaine (immunologie), Humains, Immunoglobuline A sécrétoire (analyse), Muqueuse nasale (immunologie), Muqueuse nasale (métabolisme), Orthomyxoviridae (immunologie), Population urbaine, Russie, Techniques immunoenzymatiques, Tests d'inhibition de l'hémagglutination, Vaccination, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie).
MESH :
- administration et posologie : Vaccins antiviraux, Vaccins atténués.
- analyse : Anticorps antiviraux, Immunoglobuline A sécrétoire.
- immunologie : Grippe humaine, Muqueuse nasale, Orthomyxoviridae, Vaccins antiviraux, Vaccins atténués.
- métabolisme : Muqueuse nasale.
- Administration par voie nasale, Adolescent, Calendrier vaccinal, Enfant, Grippe humaine, Humains, Population urbaine, Russie, Techniques immunoenzymatiques, Tests d'inhibition de l'hémagglutination, Vaccination.

English descriptors

KwdEn :
- Administration, Intranasal, Adolescent, Antibodies, Viral (analysis), Child, Hemagglutination Inhibition Tests, Humans, Immunization Schedule, Immunoenzyme Techniques, Immunoglobulin A, Secretory (analysis), Influenza, Human (immunology), Influenza, Human (prevention & control), Nasal Mucosa (immunology), Nasal Mucosa (metabolism), Orthomyxoviridae (immunology), Russia, Urban Population, Vaccination, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
MESH :
- chemical , administration & dosage : Vaccines, Attenuated, Viral Vaccines.
- chemical , analysis : Antibodies, Viral, Immunoglobulin A, Secretory.
- immunology : Influenza, Human, Nasal Mucosa, Orthomyxoviridae, Vaccines, Attenuated, Viral Vaccines.
- metabolism : Nasal Mucosa.
- prevention & control : Influenza, Human.
- Administration, Intranasal, Adolescent, Child, Hemagglutination Inhibition Tests, Humans, Immunization Schedule, Immunoenzyme Techniques, Russia, Urban Population, Vaccination.

Abstract

In Russia for prevention of influenza in children, aged from 3 to 14 years, the children's live influenza vaccine (LIV), based upon A/Leningrad/134/47/57(H2N2) master strain (LIVI) is used. The need for double immunization appears to be one out of the faulties of this preparation. The study was aimed to comparing the safety, immunogenic activity and prevention of influenza by LIV for adults (LIVII) (A/Leningrad/134/17/57(H2N2 master strain) and LIVI in children aged from 7 to 17 years under similar administration schedule. The safety, the preventive efficacy, humoral and secretory immunity were studied. In total 2486 persons, including 539 children, twice inoculated with LIVI, 971 persons once inoculated with LIVII, and 840 treated by placebo were obserbed. From the data of the clinical observations during 7 days after immunization both vaccines appeared to be low reactogenic. The LIVII advantages in induction of the humoral and secretory antibodies in comparison with children's vaccine had been revealed. Both vaccines were highly efficacious, the efficiency of both preparations was more pronounced after serologic correction of the diagnosis. The results obtained permit to recommend the single immunization by the variant of LIV at the base on A/Leningrad/134/17/57/(H2N2) master strain for prevention of influenza in school children.

PubMed: 12271721

Affiliations:

Le document en format XML

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<term>Child</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immunization Schedule</term>
<term>Immunoenzyme Techniques</term>
<term>Immunoglobulin A, Secretory (analysis)</term>
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<term>Enfant</term>
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<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Immunoglobuline A sécrétoire (analyse)</term>
<term>Muqueuse nasale (immunologie)</term>
<term>Muqueuse nasale (métabolisme)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Population urbaine</term>
<term>Russie</term>
<term>Techniques immunoenzymatiques</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (administration et posologie)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins atténués (administration et posologie)</term>
<term>Vaccins atténués (immunologie)</term>
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<term>Viral Vaccines</term>
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<term>Immunoglobulin A, Secretory</term>
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<term>Vaccins atténués</term>
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<term>Immunoglobuline A sécrétoire</term>
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<term>Muqueuse nasale</term>
<term>Orthomyxoviridae</term>
<term>Vaccins antiviraux</term>
<term>Vaccins atténués</term>
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<term>Nasal Mucosa</term>
<term>Orthomyxoviridae</term>
<term>Vaccines, Attenuated</term>
<term>Viral Vaccines</term>
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<term>Adolescent</term>
<term>Child</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immunization Schedule</term>
<term>Immunoenzyme Techniques</term>
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<term>Urban Population</term>
<term>Vaccination</term>
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<term>Calendrier vaccinal</term>
<term>Enfant</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Population urbaine</term>
<term>Russie</term>
<term>Techniques immunoenzymatiques</term>
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<front><div type="abstract" xml:lang="en">In Russia for prevention of influenza in children, aged from 3 to 14 years, the children's live influenza vaccine (LIV), based upon A/Leningrad/134/47/57(H2N2) master strain (LIVI) is used. The need for double immunization appears to be one out of the faulties of this preparation. The study was aimed to comparing the safety, immunogenic activity and prevention of influenza by LIV for adults (LIVII) (A/Leningrad/134/17/57(H2N2 master strain) and LIVI in children aged from 7 to 17 years under similar administration schedule. The safety, the preventive efficacy, humoral and secretory immunity were studied. In total 2486 persons, including 539 children, twice inoculated with LIVI, 971 persons once inoculated with LIVII, and 840 treated by placebo were obserbed. From the data of the clinical observations during 7 days after immunization both vaccines appeared to be low reactogenic. The LIVII advantages in induction of the humoral and secretory antibodies in comparison with children's vaccine had been revealed. Both vaccines were highly efficacious, the efficiency of both preparations was more pronounced after serologic correction of the diagnosis. The results obtained permit to recommend the single immunization by the variant of LIV at the base on A/Leningrad/134/17/57/(H2N2) master strain for prevention of influenza in school children.</div>
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Serveur d'exploration H2N2

[The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years].

[The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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